Probably an obscure issue I’ll never experience again, but in case it does, I found a solution that worked in a thread on Yahoo Answers.
Run one of the commands below in a Command Prompt or just stick it into the Run dialog (win + r). Then restart Skype *sigh*… 🙄
Windows XP
Windows 7 (and Vista?)
Note: You may of course also find and delete the file by using Windows Explorer. I just prefer a quick one-off command 🙂
/a